Cytomegalovirus antigen within human arterial smooth muscle cells
| Autor: | Joseph L. Melnick, Gordon R. Dreesman, B. L. Petrie, Joyce Burek, Michael E. DeBakey, C. H. McCollum |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Human cytomegalovirus
Pathology medicine.medical_specialty Arteriosclerosis Congenital cytomegalovirus infection Cytomegalovirus Fluorescent Antibody Technique Biology Immunofluorescence medicine.disease_cause Muscle Smooth Vascular Antigen medicine.artery medicine Humans Antigens Viral Cells Cultured Aorta medicine.diagnostic_test General Medicine Arteries medicine.disease Virology Microscopy Electron Herpes simplex virus medicine.anatomical_structure Cell culture Artery |
| Zdroj: | Lancet (London, England). 2(8351) |
| ISSN: | 0140-6736 |
| Popis: | Arterial tissues from carotid artery plaques or from punch-biopsy samples of uninvolved areas of the aorta were removed from 132 patients with atherosclerosis during blood-vessel surgery. Cells morphologically identical to smooth muscle cells were cultured from 26 to 126 plaque samples and from 6 of 6 punch-biopsy samples. Immunofluorescence tests of these cells showed that more than 25% of the cell cultures from both types of sample contained antigens of human cytomegalovirus (CMV) but not of herpes simplex virus type 1 or type 2. Replicating CMV was not detected by electron microscopy in the antigen-positive cells, suggesting that the artery walls may be a site of CMV latency. |
| Databáze: | OpenAIRE |
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