Effect of insulin with oral nutrients on whole-body protein metabolism in growing pubertal children with type 1 diabetes
| Autor: | Ieva Braziuniene, Jeremy Garlick, Izolda Mileva, Margaret A. McNurlan, Thomas A. Wilson, Vardhini Desikan |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent medicine.medical_treatment Protein metabolism Nutritional Status chemistry.chemical_compound Nutrient Insulin Infusion Systems Oral administration Internal medicine Diabetes mellitus medicine Dietary Carbohydrates Humans Hypoglycemic Agents Insulin Amino Acids Pancreatic hormone Type 1 diabetes business.industry Puberty Proteins Metabolism medicine.disease Dietary Fats Kinetics Endocrinology Diabetes Mellitus Type 1 Treatment Outcome chemistry Pediatrics Perinatology and Child Health Female Dietary Proteins business |
| Zdroj: | Pediatric research. 65(1) |
| ISSN: | 1530-0447 |
| Popis: | Insulin treatment of children with insulin-dependent diabetes mellitus improves whole body protein balance. Our recent study, conducted in pubertal children with type 1 diabetes with provision of both insulin and amino acids, indicated a positive effect of insulin on protein balance, primarily through decreased protein degradation. The current study was undertaken to assess the effect of insulin on protein metabolism in adolescents with type 1 diabetes during oral provision of a complete diet. Whole-body protein metabolism in six pubertal children (13-17 y) with type 1 diabetes mellitus was assessed with L-[1-13C]leucine during a basal (insulin-withdrawn) period and during infusion of 0.15 U/kg/h regular insulin with hourly meals to meet protein and energy requirements. Net leucine balance was significantly higher with insulin and nutrients (13.1 +/- 6.3 micromol leucine/kg/h) than in the basal state (-21.4 +/- 2.8, p0.01) with protein degradation decreased from 138 +/- 5.6 mumol leucine/kg/h to 108 +/- 5.9 (p0.01) and no significant change in protein synthesis. Even with an ample supply of nutrients, insulin does not increase whole-body protein synthesis in pubertal children with type 1 diabetes mellitus and positive protein balance is solely due to a substantial reduction in the rate at which protein is degraded. |
| Databáze: | OpenAIRE |
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