DeubiKuitylation: A novel DUB enzymatic activity for the DNA repair protein, Ku70
| Autor: | Haim Y. Cohen, Batya Lerrer, Moran Rathaus |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
DNA Repair
DNA repair Apoptosis Biology Mitochondrion Histones DNA Repair Protein Animals Humans Ku Autoantigen Molecular Biology bcl-2-Associated X Protein chemistry.chemical_classification Ku70 Antigens Nuclear Cell Biology Telomere Chromatin Cell biology DNA-Binding Proteins Enzyme chemistry Ubiquitin Thiolesterase Function (biology) Signal Transduction Developmental Biology |
| Zdroj: | Cell Cycle. 8:1843-1852 |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.4161/cc.8.12.8864 |
| Popis: | The Ku70 protein was shown to be involved in multiple cellular pathways including DNA repair, telomere maintenance, V(D)J recombination and Bax mediated apoptosis. Yet, despite this wide spectrum of pathways, until recently the enzymatic activity of Ku70 was elusive. Recent findings demonstrate that Ku70 is associated with the proapoptotic protein Bax and possesses a deubiquitin enzyme (DUB) activity on it. These data suggest a dual role for Ku70 in apoptotic regulation; on one hand the association with Ku70 sequestered Bax away from the mitochondria and plays an antiapoptotic function. On the other hand, this association mediates and promotes Bax deubiquitylation which will block its labeling for proteasomal degradation and in this manner Ku70 will have a proapoptotic role. The exciting finding of Ku70's DUB activity opens numerous avenues for future research. Here we suggest candidate substrate proteins and indicate how the DUB activity of Ku70 on these, might affect the known Ku70's related pathways. |
| Databáze: | OpenAIRE |
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