Bioactivities of water-soluble polysaccharides from Jisongrong mushroom: anti-breast carcinoma cell and antioxidant potential
| Autor: | Bin Chen, Lin-Bin Zhou |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Arabinose
Male Antioxidant Rhamnose medicine.medical_treatment Mannose Antineoplastic Agents Breast Neoplasms Xylose Polysaccharide Biochemistry Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Structural Biology Polysaccharides medicine Animals Molecular Biology chemistry.chemical_classification Glutathione Peroxidase Superoxide Dismutase Water General Medicine Catalase Glutathione Rats Glutathione Reductase chemistry Solubility Galactose Female Drug Screening Assays Antitumor Agaricales Phytotherapy |
| Zdroj: | International journal of biological macromolecules. 48(1) |
| ISSN: | 1879-0003 |
| Popis: | Polysaccharides were extracted from Jisongrong mushroom. Jisongrong polysaccharides was a water-soluble compound. Its molecular weight was about 7.4 × 10 4 Da. HPLC analysis showed that this polysaccharides was composed of mannose, ribose, rhamnose, glucose, xylose, galactose and arabinose in the molar contents of 3.3, 17.3, 6.0, 12.4, 98.4 and 2.1 μM, respectively. In the range of 2800–3500 cm −1 , peaks at 2958 and 3407 cm −1 belonging to –C–H of –CH 2 groups, were observed in polysaccharides. When Jisongrong polysaccharides were orally administrated to rats for 2 months, level of lipid peroxidation products and activities of antioxidant enzymes in the blood were significantly decreased and enhanced compared to control rats. Moreover, Jisongrong polysaccharides still markedly inhibited cancer cells proliferation. These results suggested that Jisongrong polysaccharides possess a strong antioxidant and antitumour activities. |
| Databáze: | OpenAIRE |
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