Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia

Autor: Barbara De Moerloose, Ninna Bager, Zhanna Kovalova, Berna Beverloo, Bernward Zeller, Eigil Kjeldsen, Julie Damgaard Sandahl, Birgitte Lausen, Olafur G. Jonsson, Eveline S. J. M. de Bont, Kirsi Jahnukainen, Henrik Hasle, Gertjan L. Kaspers, Kadri Saks, Josefine Palle, Ulrika Norén-Nyström, Kristian Løvvik Juul-Dam, Shau-Yin Ha, Jonas Abrahamsson
Přispěvatelé: Clinical Genetics, Pediatric surgery, CCA - Cancer biology and immunology
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: British Journal of Haematology, 183(4), 618-628. Wiley-Blackwell Publishing Ltd
Bager, N, Juul-Dam, K L, Sandahl, J D, Abrahamsson, J, Beverloo, B, de Bont, E S J M, Ha, S-Y, Jahnukainen, K, Jónsson, Ó G, Kaspers, G L, Kovalova, Z, Lausen, B, de Moerloose, B, Noren-Nyström, U, Palle, J, Saks, K, Zeller, B, Kjeldsen, E & Hasle, H 2018, ' Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study ', British Journal of Haematology, vol. 183, no. 4, pp. 618-628 . https://doi.org/10.1111/bjh.15587
Bager, N, Juul-Dam, K L, Sandahl, J D, Abrahamsson, J, Beverloo, B, de Bont, E S J M, Ha, S-Y, Jahnukainen, K, Jónsson, Ó G, Kaspers, G L, Kovalova, Z, Lausen, B, De Moerloose, B, Noren-Nyström, U, Palle, J, Saks, K, Zeller, B, Kjeldsen, E & Hasle, H 2018, ' Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study ', British Journal of Haematology, vol. 183, no. 4, pp. 618-628 . https://doi.org/10.1111/bjh.15587
British Journal of Haematology, 183(4), 618-628. Wiley
British Journal of Haematology, 183(4), 618-628. Wiley-Blackwell
ISSN: 1365-2141
0007-1048
DOI: 10.1111/bjh.15587
Popis: Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993-2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2·1 and 3·3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1·43, P = 0·03) and overall survival (OS; HR 1·48, P = 0·01). MK was associated with a poor EFS (HR 1·57, P = 0·03) but did not show an inferior OS compared to non-MK patients (HR 1·14, P = 0·62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis.
Databáze: OpenAIRE
Externí odkaz: