Computer Optimization of Pharmaceutical Formulations I: General procedure
| Autor: | Joseph B. Schwartz, Robert H. Press, Joel R. Flamholz |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Mathematical optimization
Polynomial Time Factors Variables Computers Computer science Drug Compounding media_common.quotation_subject Pharmaceutical Science Regression analysis Set (abstract data type) Computer analysis Solubility Hardness Regression Analysis Data input Computer optimization Selection (genetic algorithm) Tablets media_common |
| Zdroj: | Journal of Pharmaceutical Sciences. 62:1165-1170 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600620722 |
| Popis: | A technique was developed whereby a formulation with optimum properties, according to predetermined criteria, can be selected via computer analysis. The results of a statistically designed set of experiments based on five independent variables were used as the data input to the computer. Regression analysis of these data resulted in a set of second-order polynomial predictor equations. Restrictions placed by the pharmacist on the characteristics of interest serve to eliminate undesirable formulations. Ultimately, the formulator can trade off properties to obtain an optimum formulation. Computer-generated graphs further aid the formulator in the understanding of the particular system. An example is presented of the selection of an optimum formulation by this procedure and of its preparation in the laboratory. Predictions and experimental results show excellent agreement. |
| Databáze: | OpenAIRE |
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