Mixed lymphocyte reaction in interferon-.GAMMA. treated(NZB*NZW)F1 mice
| Autor: | Mitsuhiro Higashikawa, Hitoshi Sugishima, Atsushi Horiuchi, Masanori Funauchi, Keizou Ikeda, Masahide Minoda |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
T-Lymphocytes
Kidney Glomerulus Fluorescent Antibody Technique Spleen General Biochemistry Genetics and Molecular Biology Immunoglobulin G Interferon-gamma Mice Antigen immune system diseases medicine Animals Interferon gamma skin and connective tissue diseases Proteinuria biology Chemistry Macrophages Histocompatibility Antigens Class II DNA General Medicine T lymphocyte Mixed lymphocyte reaction Mice Inbred C57BL medicine.anatomical_structure Immunoglobulin M Antibodies Antinuclear Immunology biology.protein Female Lymphocyte Culture Test Mixed medicine.symptom medicine.drug |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 158:155-161 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.158.155 |
| Popis: | Mouse interferon-gamma was administered to (NZB x NZW)F1 mice, which develop a disease like human systemic lupus erythematosus. Class II antigens on adherent spleen cells and their activity to stimulate allogeneic T lymphocyte in mixed lymphocyte reaction were observed as well as the changes of the clinical findings of the mice. In interferon-gamma treated mice, as compared to control mice, the positive rate for class II antigen on adherent spleen cells was increased, and the mixed lymphocyte reaction using the cells of interferon-gamma treated mice as stimulator cells was enhanced. These findings suggest that the enhancement of antigen presenting activity of adherent spleen cells to T lymphocytes might be associated in the exacerbation of the disease in interferon-gamma treated (NZB x NZW)F1 mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|