Green Synthesis of Bromo Organic Molecules and Investigations on Their Antibacterial Properties: An Experimental and Computational Approach
| Autor: | Pranjal Bharali, Naruti Longkumer, Aola Supong, Upasana Bora Sinha, Latonglila Jamir, Kikoleho Richa, Visekhonuo Kuotsu, Rituparna Karmaker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Klebsiella pneumoniae
In silico Bacillus subtilis medicine.disease_cause 01 natural sciences lcsh:Chemistry chemistry.chemical_compound green medicine Escherichia coli Tribromide General Environmental Science Bromo compounds biology 010405 organic chemistry aqueous in vitro molecular docking biology.organism_classification Antimicrobial Combinatorial chemistry 0104 chemical sciences antibacterial chemistry lcsh:QD1-999 Yield (chemistry) General Earth and Planetary Sciences Antibacterial activity |
| Zdroj: | Acta Chimica Slovenica, Vol 66, Iss 2, Pp 276-283 (2019) |
| ISSN: | 1580-3155 1318-0207 |
| Popis: | A simple, environmentally benign methodology has been developed to synthesize some bromoorganic compounds which have potential as antimicrobial agents. The required compounds were obtained through microwave (MW) irradiation, on-water reactions and using cetyltrimethylammonium tribromide (CTMATB) as the bromine source. The high yield of the product could be achieved within short reaction times, thus representing the main attribute of the present synthetic approach. The compounds were evaluated for in vitro antibacterial activity against Escherichia coli, Klebsiella pneumoniae , Staphylococcus aureus and Bacillus subtilis . Further, in silico studies were carried out to elucidate the interactions of the compounds with the bacterial proteins. |
| Databáze: | OpenAIRE |
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