Mammary Analogue Secretory Carcinoma of Salivary Gland – A Diagnostic Dilemma
| Autor: | Ganesh Rk Shirsagar, Nitin M Gadgil, Prashant Vijay Kumavat, Chetan Sudhakar Chaudhari, Shruti Chandrakar |
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| Rok vydání: | 2017 |
| Předmět: |
histopathological
Pathology medicine.medical_specialty adenocarcinoma Salivary gland business.industry Mammary analogue secretory carcinoma lcsh:R Clinical Biochemistry lcsh:Medicine 030206 dentistry General Medicine Diagnostic dilemma 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure stomatognathic system 030220 oncology & carcinogenesis medicine business acinic cell |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 12, Pp ED13-ED14 (2017) |
| ISSN: | 2249-782X |
| DOI: | 10.7860/jcdr/2017/32246.10961 |
| Popis: | Mammary Analogue Secretory Carcinoma (MASC) of salivary gland is a recently described entity with unique morphologic, clinical and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast. Before their initial description, these salivary gland tumours were generally diagnosed as acinic cell carcinoma or adenocarcinoma. We present a case of 32-year-old, male presenting with painless swelling over left cheek which was gradually increasing in size. The histopathological examination of the lesion was done and two possible differential diagnosis were acinic cell carcinoma (papillary cystic variant) and MASC of the parotid gland. Immunohistochemistry was performed which demonstrated combined positivity for S-100, mammglobin, CK-7 and DOG-1 negativity which confirmed the diagnosis of MASC of parotid. |
| Databáze: | OpenAIRE |
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