Measuring the composition-curvature coupling in binary lipid membranes by computer simulations
| Autor: | C. Pastorino, I. A. Barragán Vidal, Carla M. Rosetti, Marcus Müller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Analytical chemistry
General Physics and Astronomy Thermal fluctuations Quantitative Biology::Cell Behavior Quantitative Biology::Subcellular Processes purl.org/becyt/ford/1 [https] Membrane Lipids Phenomenological model Doping purl.org/becyt/ford/1.4 [https] Computer Simulation Lipid bilayer phase behavior Physical and Theoretical Chemistry Free energy Lipid bilayer Monolayers Physics::Biological Physics Chemistry Otras Ciencias Químicas Bilayer Ciencias Químicas Membrane structure Lipid Membrane Chemical physics Thermodynamics Critical point phenomena Membrane biophysics CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | The coupling between local composition fluctuations in binary lipid membranes and curvatureaffects the lateral membrane structure. We propose an efficient method to compute the composition-curvature coupling in molecular simulations and apply it to two coarse-grained membrane models—aminimal, implicit-solvent model and the MARTINI model. Both the weak-curvature behavior that istypical for thermal fluctuations of planar bilayer membranes as well as the strong-curvature regimecorresponding to narrow cylindrical membrane tubes are studied by molecular dynamics simulation.The simulation results are analyzed by using a phenomenological model of the thermodynamics ofcurved, mixed bilayer membranes that accounts for the change of the monolayer area upon bending.Additionally the role of thermodynamic characteristics such as the incompatibility between thetwo lipid species and asymmetry of composition are investigated. Fil: Barragán Vidal, I. A.. Georg August Universität, Gottingen; Alemania Fil: Rosetti, Carla Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Pastorino, Claudio. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Müller, M.. Georg August Universität, Gottingen; Alemania |
| Databáze: | OpenAIRE |
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