Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model

Autor: Olubukola Benedicta, Ojo, Zainab Abiola, Amoo, Mary Tolulope, Olaleye, Sushil Kumar, Jha, Afolabi Clement, Akinmoladun
Rok vydání: 2022
Předmět:
Zdroj: Neurochemical Research. 48:96-116
ISSN: 1573-6903
0364-3190
DOI: 10.1007/s11064-022-03732-8
Popis: Strict metabolic regulation in discrete brain regions leads to neurochemical changes in cerebral ischemia. Accumulation of extracellular glutamate is one of the early neurochemical changes that take place during cerebral ischemia. Understanding the sequential neurochemical processes involved in cerebral ischemia-mediated excitotoxicity before the clinical intervention of revascularization and reperfusion may greatly influence future therapeutic strategies for clinical stroke recovery. This study investigated the influence of time and brain regions on excitatory neurochemical indices in the bilateral common carotid artery occlusion (BCCAO) model of global ischemia. Male Wistar rats were subjected to BCCAO for 15 and 60 min to evaluate the effect of ischemia duration on excitatory neurochemical indices (dopamine level, glutamine synthetase, glutaminase, glutamate dehydrogenase, aspartate aminotransferase, monoamine oxidase, acetylcholinesterase, and Na
Databáze: OpenAIRE
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