Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure

Autor: Maryam Sadr, Mona Hedayat, Sara Harsini, Nilufar Esfahanian, Elham Farhadi, A. A. Amirzargar, Mehdi Mahmoudi, Nima Rezaei, Keramat Nourijelyani, Morteza Mahmoudi, Ebrahim Nematipour, Mohammad Taghvaei
Rok vydání: 2016
Předmět:
Adult
Male
Economics and Econometrics
Genotype
Interleukin-1beta
Myocardial Ischemia
Single-nucleotide polymorphism
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
030226 pharmacology & pharmacy
01 natural sciences
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Interleukin-1alpha
Materials Chemistry
Media Technology
medicine
Humans
Genetic Predisposition to Disease
Allele
Alleles
Aged
DNA Primers
Heart Failure
business.industry
Receptors
Interleukin-1
Interleukin
Forestry
Middle Aged
medicine.disease
0104 chemical sciences
Genotype frequency
Interleukin 1 Receptor Antagonist Protein
010404 medicinal & biomolecular chemistry
Interleukin 1 receptor antagonist
Case-Control Studies
Multigene Family
Heart failure
Immunology
Interleukin-6 receptor
Female
business
Interleukin-1
Zdroj: Europe PubMed Central
ISSN: 1336-0345
Popis: BACKGROUND: Proinfl ammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinfl ammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1a, IL-1I², and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease. METHODS: Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specifi c primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL- 1a (-889), IL-1I² (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.RESULTS: The frequency of the IL-1I² -511/C allele was signifi cantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1I² (-511) C/C genotype was signifi cantly overrepresented in patients compared to controls (p = 0.022). CONCLUSIONS: Particular allele and genotype in IL-1I² gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27). Text in PDF www.elis.sk.
Databáze: OpenAIRE
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