Suppression of Helicobacter pylori infection by daily cranberry intake: A double‐blind, randomized, placebo‐controlled trial
| Autor: | Jing-Ying Zhang, Zhe-Xuan Li, Tong Zhou, Ha-Er Gao, Wei-Cheng You, Yang Zhang, Dong-Man Ye, Xiao-Ying Guo, Wei-Dong Liu, Kai-Feng Pan, Jun-Ling Ma, Yang Guo, Wen-Qing Li, Lan-fu Zhang, Ming Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Dose Adolescent Placebo-controlled study Placebo Gastroenterology law.invention Helicobacter Infections 03 medical and health sciences Eating Young Adult 0302 clinical medicine food Randomized controlled trial Double-Blind Method law Internal medicine Prevalence Medicine Humans Cranberry Proanthocyanidins food.beverage Suppression Hepatology biology Helicobacter pylori business.industry Incidence (epidemiology) CRANBERRY JUICE Middle Aged biology.organism_classification Placebo Effect Fruit and Vegetable Juices Clinical Gastroenterology Treatment Outcome Vaccinium macrocarpon Proanthocyanidin 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Randomized clinical trial business Regular Articles |
| Zdroj: | Journal of Gastroenterology and Hepatology |
| ISSN: | 1440-1746 0815-9319 |
| Popis: | Background and aim Dietary strategies that contribute to reducing incidence of Helicobacter pylori infection without negative side effects are highly desirable owing to worldwide bacterial prevalence and carcinogenesis potential. The aim of this study was to determine dosage effect of daily cranberry consumption on H. pylori suppression over time in infected adults to assess the potential of this complementary management strategy in a region with high gastric cancer risk and high prevalence of H. pylori infection. Methods This double‐blind, randomized, placebo‐controlled trial on 522 H. pylori‐positive adults evaluated dose–response effects of proanthocyanidin‐standardized cranberry juice, cranberry powder, or their placebos on suppression of H. pylori at 2 and 8 weeks by 13C‐urea breath testing and eradication at 45 days post‐intervention. Results H. pylori‐negative rates in placebo, low‐proanthocyanidin, medium‐proanthocyanidin, and high‐proanthocyanidin cranberry juice groups at week 2 were 13.24%, 7.58%, 1.49%, and 13.85% and at week 8 were 7.35%, 7.58%, 4.48%, and 20.00%, respectively. Consumption of high‐proanthocyanidin juice twice daily (44 mg proanthocyanidin/240‐mL serving) for 8 weeks resulted in decreased H. pylori infection rate by 20% as compared with other dosages and placebo (P |
| Databáze: | OpenAIRE |
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