Single Photon Emission Computerised Tomography in Chronic Alcoholism
| Autor: | Mehmet Araç, Asli Çepik Kuruoğlu, Erdal Işik, Gülin Vural, Metin Karataş, Zehra Arikan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Turkey media_common.quotation_subject Central nervous system Hemodynamics Comorbidity 03 medical and health sciences 0302 clinical medicine Atrophy Internal medicine Reaction Time medicine Humans Personality 030212 general & internal medicine skin and connective tissue diseases Psychiatry media_common Tomography Emission-Computed Single-Photon Brain Mapping Antisocial personality disorder Brain Antisocial Personality Disorder Middle Aged medicine.disease Frontal Lobe 030227 psychiatry Alcoholism Psychiatry and Mental health medicine.anatomical_structure Cerebral blood flow Frontal lobe Regional Blood Flow Evoked Potentials Auditory Cardiology Female sense organs Psychology Perfusion Blood Flow Velocity |
| Zdroj: | British Journal of Psychiatry. 169:348-354 |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | BackgroundWe examined the functional and structural cerebral changes in chronic alcoholics, analysing their association with personality features and alcohol drinking habits.MethodForty patients with alcohol dependency, including 15 with antisocial personality disorder (ASP) as defined in DSM–III–R and 10 age and sex matched healthy controls were studied after termination of withdrawal symptoms, using high resolution single photon emission tomography (SPECT), cranial computerised tomography (CT) and brainstem auditory evoked potentials (BAEP).ResultsWe found significant reductions in regional cerebral blood flow (rCBF) measurements of alcoholic patients. Low flow in frontal regions encountered in 67.5% of the patients was associated with the duration of alcohol consumption, while no such relation existed with the amount of daily intake. Patients with ASP exhibited more marked frontal hypoperfusion. Significant brain atrophy detected by CT was present in 40% of the patients and did not correlate with frontal hypoperfusion.ConclusionsPatients with ASP are more sensitive to toxic effects of alcohol. Alternatively chronic alcoholism leads to frontal lobe dysfunction recognised as ASP in the clinical setting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|