Histologic analysis of bioabsorbable scleral buckling implants: an experimental study on rabbits
| Autor: | Satu Länsman, Heli Hirvelä, Jorma Ryhänen, Pertti Törmälä, Ville Ellä, Timo Waris, Nureddin Ashammakhi, Paavo Pääkkö, Minna Kellomäki |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Biocompatibility Polyesters Biocompatible Materials Prosthesis Implantation chemistry.chemical_compound Silicone Fibrosis Absorbable Implants Materials Testing Medicine Animals business.industry Foreign-Body Reaction Macrophages Histology General Medicine Prostheses and Implants medicine.disease Surgery Sclera Ophthalmology Scleral Buckling medicine.anatomical_structure chemistry Eye Foreign Bodies Silicone Elastomers Implant Rabbits business Scleral buckling |
| Zdroj: | Tampere University |
| ISSN: | 0275-004X |
| Popis: | PURPOSE To analyze histologically tissue reactions to bioabsorbable PLA96 in rabbit eyes. METHODS Scleral buckling operations were carried out in 48 rabbits. Two materials were used: bioabsorbable PLA96 (polylactide 96/4; L/D molar ratio 96/4) and silicone sponge. One eye of each rabbit was operated on and the other eye served as a nonoperated control. After follow-up times of 1, 3, 5, and 12 months, the rabbits were killed and the eyes enucleated for histology. RESULTS All rabbits recovered well. Histologically, tissue reactions were very localized; implant fragments were not seen within the sclera. The amounts of fibrous tissue and inflammatory cells (mainly macrophages) inside the implant area increased over time. One rabbit from the silicone group was killed 4 months postoperatively owing to refusal to eat. In the PLA96 group, acute or chronic infections occurred in four rabbits. The bioabsorbable implant was macroscopically easily detectable at 12 months postoperatively. CONCLUSIONS The PLA96 material used for scleral buckling in rabbits showed good biocompatibility. The material did not undergo biodegradation during the follow-up period of 12 months. PLA96 implants were associated with thicker fibrous tissue encapsulation and more inflammatory cells compared with silicone sponge implants. |
| Databáze: | OpenAIRE |
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