Effectiveness of a nursing support program for patients with recurrent ovarian cancer receiving pegylated liposomal doxorubicin (Caelyx®/Doxil®)
| Autor: | M. Gill, Jean-François Pouliot, V. Lebel, K. Mitchinson, T. Mullen, N. Grenier, K. Sebborn |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Canada medicine.medical_specialty Vomiting Nausea medicine.medical_treatment Nurse's Role lcsh:RC254-282 Drug Administration Schedule Polyethylene Glycols Patient Education as Topic Internal medicine Mucositis medicine Humans Doxorubicin Paresthesia Prospective Studies Prospective cohort study Fatigue Ovarian Neoplasms Stomatitis Chemotherapy business.industry Incidence Oncology Nursing Social Support General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Surgery Discontinuation Nursing Evaluation Research Tolerability Patient Compliance Female lipids (amino acids peptides and proteins) Neoplasm Recurrence Local medicine.symptom Ovarian cancer business Dermatitis Exfoliative Program Evaluation medicine.drug |
| Zdroj: | Canadian Oncology Nursing Journal, Vol 17, Iss 3, Pp 133-136 (2007) |
| ISSN: | 1181-912X |
| DOI: | 10.5737/1181912x173133136 |
| Popis: | Pegylated liposomal doxorubicin (PLD) has become the preferred alternative for ovarian cancer patients who have failed platinum-based therapy, but side effects, such as palmar-plantar erythrodysesthesia (PPE), may lead to sub-optimal drug exposure and treatment discontinuation. A prospective Canadian multicentre open-label study evaluated the effects of a nurse-administered education and support program on treatment adherence and tolerability in 112 women with recurrent ovarian cancer. Subjects received an average of four four-week PLD cycles, the recommended number of courses required to evaluate the efficacy from PLD. Side effects were common, but 75% of patients were able to complete > 3 cycles and 59% completed > 4 cycles of PLD chemotherapy. With proactive nursing intervention, the incidence of PLD-associated grade three-four toxicities such as PPE and mucositis was substantially decreased. Nursing intervention may allow more patients to receive chemotherapy on schedule, thus reproducing the conditions of the clinical study in which the efficacy of the drug has been established. |
| Databáze: | OpenAIRE |
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