Relationship between Adrenal Gland and Properdin Level
| Autor: | Graber H, Ivan E, Gy. Somogyi, L. Biró |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
medicine.medical_specialty
Physiology Prednisolone medicine.medical_treatment chemical and pharmacologic phenomena urologic and male genital diseases General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine Adrenal Glands Medicine Desoxycorticosterone Aldosterone Pharmacology Properdin business.industry Adrenal gland Adrenal cortex Research Adrenalectomy Zymosan General Medicine female genital diseases and pregnancy complications Rats Cortisone medicine.anatomical_structure Endocrinology chemistry business Hormone medicine.drug |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 83:196-204 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.83.196 |
| Popis: | The investigations into the relationship between the adrenal cortex and the properdin level have revealed the following: 1. Under the effect of a stress the properdin level decreases. 2. Adrenalectomy considerably decreases the properdin level. 3. On examining the effect of the various cortical hormones, the following facts could be establshed: the deep fall of the properdin level in the untreated group is lessened by prednisolone and increased by DOCA, whereas it is completely counteracted by aldosterone and cortisone displaying mineralo-and glycocorticoid properties. In the case of normal adrenal function, the properdin level is decrea-sed by cortisone DOCA and prednisolone treatments, but it hardly changes under the effect of aldosterone. 4. By a regular zymosan treatment the amount of properdin, after a transi-tional increase of the level, can be completely exhausted. The adrenal gland has probably something to do with it, although the exact nature of its function has not yet been clarified. 5. In adrenalectomized and zymosan-treated rats, after the temporary maintenance of the initial level, the exhaustion sets in earlier. |
| Databáze: | OpenAIRE |
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