2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus type 1 and 2
| Autor: | Karin Edlund, Koushikul Islam, Tomas Bergström, Mikael Elofsson, Ya-Fang Mei, Göran Wadell, Christopher T. Öberg, Annika Allard, Mårten Strand |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Viral Plaque Assay Infectious Medicine Herpesvirus 2 Human viruses Acyclovir Infektionsmedicin Herpesvirus 1 Human Biology Herpes simplex virus medicine.disease_cause Antiviral Agents Cercopithecus aethiops Cell Line Microbiology chemistry.chemical_compound 2-[2-(benzoylamino)benzoylamino]benzoic acid Chlorocebus aethiops Drug Resistance Viral medicine Animals Humans Pharmacology (medical) Benzoic acid Aged 80 and over Pharmacology Viral reactivation HSV Herpes Simplex Middle Aged Viral Load Virology antiviral inhibitor Infectious Diseases chemistry Cell culture Benzamides Benzavir Female Viral load |
| Popis: | Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are responsible for lifelong latent infections in humans, with periods of viral reactivation associated with recurring ulcerations in the orofacial and genital tracts. In immunosuppressed patients and neonates, HSV infections are associated with severe morbidity and, in some cases, even mortality. Today, acyclovir is the standard therapy for the management of HSV infections. However, the need for novel antiviral agents is apparent, since HSV isolates resistant to acyclovir therapy are frequently isolated in immunosuppressed patients. In this study, we assessed the anti-HSV activity of the antiadenoviral compounds 2-[2-(2-benzoylamino)-benzoylamino]benzoic acid (benzavir-1) and 2-[4,5-difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid (benzavir-2) on HSV-1 and HSV-2. Both compounds were active against both viruses. Importantly, benzavir-2 had potency similar to that of acyclovir against both HSV types, and it was active against clinical acyclovir-resistant HSV isolates. |
| Databáze: | OpenAIRE |
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