Familial Mediterranean fever in Arabs
| Autor: | Hasan Abdel Majeed, Mohammed El-Khateeb, Hatem El-Shanti |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Familial Mediterranean fever Ethnic origin Recurrent acute Pyrin domain Gout Suppressants Recurrence medicine Humans Renal Insufficiency Child Hereditary Periodic Fever Syndromes business.industry Amyloidosis Autoantibody General Medicine Pyrin medicine.disease MEFV Dermatology Arabs Familial Mediterranean Fever Cytoskeletal Proteins Phenotype Mutation Female Colchicine business |
| Zdroj: | The Lancet. 367:1016-1024 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(06)68430-4 |
| Popis: | Summary Autoinflammatory diseases are a group of disorders characterised by seemingly unprovoked inflammation in the absence of high-titre autoantibodies or antigen-specific T cells, and include the hereditary periodic fever syndromes. Familial Mediterranean fever (FMF) is an archetypal autoinflammatory disorder, which is autosomal recessive and has a high prevalence in non-Ashkenazi Jews, Armenians, Turks, and Arabs. The classic clinical picture is recurrent acute short-lived febrile and painful attacks with variable periods of remission. In a subset of patients, the disorder is complicated by amyloidosis that leads to renal failure. The gene responsible for FMF— MEFV —has been identified and its role in inflammation is being assessed. There seems to be a distinctive clinical picture in Arab patients with FMF, and the range and distribution of MEFV mutations is different from that noted in other affected ethnic groups. Here, we discuss the clinical and molecular aspects of FMF in Arabs. |
| Databáze: | OpenAIRE |
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