Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas
| Autor: | Jacks Jorge, Maria Letícia Cintra, Karina G. Zecchin, Oslei Paes de Almeida, Rafael Fantelli Stelini, Marcondes Sena-Filho, Camilla F. Borges, Edgard Graner, Ciro Dantas Soares |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Cancer Research Skin Neoplasms Proliferation index Angiogenesis AKT1 Dermatology 03 medical and health sciences 0302 clinical medicine Medicine Humans Phosphorylation Melanoma Survival analysis Aged Aged 80 and over Tissue microarray Cell growth business.industry Middle Aged medicine.disease Prognosis Survival Analysis 030104 developmental biology Oncology Cyclooxygenase 2 030220 oncology & carcinogenesis Cancer research Immunohistochemistry Female business Proto-Oncogene Proteins c-akt |
| Zdroj: | Melanoma research. 27(5) |
| ISSN: | 1473-5636 |
| Popis: | Cyclooxygenase 2 (COX-2) and phosphorylated Akt1 (p-Akt1) are associated with tumor spreading, cell proliferation, high metabolism, and angiogenesis in solid tumors. This study aimed to investigate COX-2 and p-Akt1 expression in primary and metastatic melanomas by correlating with the cellular proliferation index (as revealed by minichromosome maintenance 2 expression) and the outcome of patients with malignant melanomas. Seventy-seven biopsies of malignant melanomas, including 42 primary nonmetastatic melanomas (PNMMs), 12 primary metastatic melanomas (PMMs), and 23 metastatic melanomas (MMs), were retrospectively selected. Tissue microarrays were developed and submitted for immunohistochemical staining for COX-2, p-Akt1, and minichromosome maintenance 2. Increased COX-2 cytoplasmic staining patterns were observed in PMM and MM when compared with PNMM (P=0.0011). Higher nuclear and cytoplasmic expression of p-Akt1 was more closely associated with PMM than with MM and PNMM (P |
| Databáze: | OpenAIRE |
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