Early effects of right ventricular volume overload on ventricular performance and β-adrenergic signaling
| Autor: | Ashish S. Shah, R.Eric Lilly, B. Zane Atkins, Jonathan A. Hata, Walter J. Koch, Oliver Tai, Donald D. Glower, Alan P. Kypson |
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| Jazyk: | angličtina |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Ventricular Dysfunction Right Hemodynamics 030204 cardiovascular system & hematology Contractility 03 medical and health sciences Dogs 0302 clinical medicine Tricuspid Valve Insufficiency GTP-Binding Proteins Internal medicine Receptors Adrenergic beta Ventricular Pressure medicine Animals Neuropeptide Y cardiovascular diseases Kinase activity 030304 developmental biology Analysis of Variance 0303 health sciences Tricuspid valve biology business.industry Myocardium Fissipedia Stroke Volume Stroke volume biology.organism_classification medicine.anatomical_structure Endocrinology Linear Models Ventricular pressure Cardiology cardiovascular system Surgery business Cardiology and Cardiovascular Medicine Adenylyl Cyclases Signal Transduction |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. (2):342-349 |
| ISSN: | 0022-5223 |
| DOI: | 10.1067/mtc.2000.107278 |
| Popis: | Objective: Right ventricular dysfunction is a poorly understood but persistent clinical problem. This study was undertaken to evaluate ventricular performance and β-adrenergic receptor signaling in a tricuspid regurgitation model of right ventricular overload. Methods: Seventeen dogs were chronically instrumented with epicardial dimension transducers. By means of the shell-subtraction model, right ventricular pressure-volume relationships were evaluated in normal and right ventricular overload states. Right ventricular chamber performance was quantified by the stroke work at an end-diastolic volume relationship. Results: Right ventricular volume overload caused a 28% ± 11% and 31% ± 9% decline in chamber performance acutely and at 1 week, respectively, whereas end-diastolic volume increased from 45 ± 21 to 60 ± 30 mL ( P =.019). β-Adrenergic receptor signaling in myocardial samples was assessed, examining adenylyl cyclase and G-protein–coupled receptor kinase activity. Stimulated adenylyl cyclase activity significantly decreased, and G-protein–coupled receptor kinase activity significantly increased in both left and right ventricular samples caused by increased levels of β-adrenergic receptor kinase 1. No change in β-adrenergic receptor density was seen at 1 week. Conclusions: Early right ventricular overload is associated with impaired right ventricular chamber contractility, dilation, and, importantly, a biventricular alteration of β-adrenergic receptor signaling. (J Thorac Cardiovasc Surg 2000;119:342-9) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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