Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Autor:	Irina O. Smirnova, Elena E. Pakhomova
Rok vydání:	2020
Předmět:	Male platelet-rich plasma (PRP) animal diseases Biopsy minoxidil CD34 Cell Count Pharmacology lcsh:Chemistry 030207 dermatology & venereal diseases 0302 clinical medicine lcsh:QH301-705.5 Spectroscopy androgenetic alopecia (AGA) integumentary system biology medicine.diagnostic_test Platelet-Rich Plasma General Medicine Combined Modality Therapy Immunohistochemistry Computer Science Applications hair morphometry Treatment Outcome medicine.anatomical_structure Minoxidil 030220 oncology & carcinogenesis Hair follicle cell proliferation Antibody Hair Follicle Ki67 medicine.drug Adult Dkk-1 Platelet Transfusion Article Catalysis Inorganic Chemistry Young Adult 03 medical and health sciences medicine Humans hair follicle cell proliferation Physical and Theoretical Chemistry Molecular Biology Cell Proliferation Scalp Cell growth business.industry Organic Chemistry Alopecia β-catenin Hair follicle nervous system diseases lcsh:Biology (General) lcsh:QD1-999 Skin biopsy biology.protein business Hair
Zdroj:	International Journal of Molecular Sciences Volume 21 Issue 18 International Journal of Molecular Sciences, Vol 21, Iss 6516, p 6516 (2020)
ISSN:	1422-0067
DOI:	10.3390/ijms21186516
Popis:	Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to &beta catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the &beta catenin and CD34 expression area increased an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.
Databáze:	OpenAIRE
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