| Autor: |
Mats Hellström, Tobias Sjöblom, Richard Rosenquist, Larry Mansouri, Viktor Ljungström, Elias Campo, Armando Lopez-Guillermo, Tycho Baumann, Jonathan C. Strefford, Stuart J. Blakemore, Ruth Clifford, Anna Schuh, Anders R. Hellström, Muhammad Akhtar-Ali, Kenneth Ban, Snehangshu Kundu, Liqun He, Jimmy Larsson, Tatjana Pandzic |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S1. schematic illustration of piggyBac transposon and transposase vectors used. PB IR refers to piggyBac inverted repeats. FRT is flippase recognition target. Supplementary Figure S2. Real-time quantitative PCR analysis confirms efficient depletion of BMP2K and DCK. Supplementary Figure S3. TP53 deficient HCT116 cell line exhibits reduced sensitivity to F-ara-A. Supplementary Figure S4. Protein expression following transient transfection of the putative fludarabine resistance genes DCK, NUDCD3, ARID5B and LARS in HCT116 cell line. Supplementary Figure S5. Vemurafinib normalizes the response to F-ara-A in cells expressing V600E mutant BRAF. Supplementary Figure S6. Hierarchical clustering of differentially expressed genes in pools of HG3 cells resistant to fludarabine. Supplementary Figure S7. Increased phosphorylation of ERK in HG3 pool resistant to fludarabine. Supplementary Figure S8. Distribution of mutations in the BRAF gene in CLL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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