Argininosuccinate synthase as a novel biomarker for inflammatory conditions

Autor:	Mengde Cao, Thomas J. George, Stanislav I. Svetlov, Victor Prima, David R. Nelson
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty Carcinoma Hepatocellular Health Toxicology and Mutagenesis Clinical Biochemistry Argininosuccinate synthase Inflammation Tumor cells Urine Biology Biochemistry Sepsis Mice Liver Neoplasms Experimental Internal medicine medicine Animals Bile Obesity Acute liver injury medicine.disease Argininosuccinate Lyase Mice Inbred C57BL Endocrinology Liver Immunology biology.protein Biomarker (medicine) medicine.symptom Biomarkers
Zdroj:	Biomarkers. 18:242-249
ISSN:	1366-5804 1354-750X
DOI:	10.3109/1354750x.2013.773080
Popis:	Argininosuccinate synthase (ASS) plays an important role in regulating metabolic functions in mammals. We previously reported that hepatic ASS is released into circulation at very high concentrations in response to endotoxin and acute liver injury. We propose that ASS may serve as a novel biomarker for various inflammatory conditions. Our data showed that ASS accumulated in serum and urine of septic, obese or tumor mice in a condition-dependent fashion. Moreover, ASS significantly increased in urine within the first week after tumor cell implantation in mice which subsequently develop tumors. These results suggest that ASS is a novel biomarker increased upon diverse inflammatory conditions.
Databáze:	OpenAIRE
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