Retrotransposition is associated with genome instability during chronological aging
| Autor: | M. Joan Curcio, Patrick H. Maxwell, William C. Burhans |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Genome instability
Genome evolution Time Factors Retroelements Cell Survival Genes Fungal Loss of Heterozygosity Retrotransposon Saccharomyces cerevisiae Chromosomal rearrangement Biology medicine.disease_cause Genome Chromosomes Telomerase and Retrotransposons: Reverse Transcriptases That Shaped Genomes Special Feature Sackler Colloquium medicine Gene Rearrangement Genetics Mutation Multidisciplinary Gene rearrangement Genome Fungal Mobile genetic elements Gene Deletion DNA Damage |
| Zdroj: | Proceedings of the National Academy of Sciences. 108:20376-20381 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Genetic damage through mutations and genome rearrangements has been hypothesized to contribute to aging. The specific mechanisms responsible for age-induced increases in mutation and chromosome rearrangement frequencies and a potential causative role for DNA damage in aging are under active investigation. Retrotransposons are mobile genetic elements that cause insertion mutations and contribute to genome rearrangements through nonallelic recombination events in humans and other organisms. We have investigated the role of endogenous Ty1 retrotransposons in aging-associated increases in genome instability using the Saccharomyces cerevisiae chronological aging model. We show that age-induced increases in loss of heterozygosity and chromosome loss events are consistently diminished by mutations or treatments that reduce Ty1 retrotransposition. Ty1 mobility is elevated in very old yeast populations, and new retromobility events are often associated with chromosome rearrangements. These results reveal a correlation between retrotransposition and genome instability during yeast aging. Retrotransposition may contribute to genetic damage during aging in diverse organisms and provides a useful tool for studying whether genetic damage is a causative factor for aging. |
| Databáze: | OpenAIRE |
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