QT interval prolongation and arrhythmia: an unbreakable connection?
| Autor: | Anderson Me |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Heart disease Heart block Long QT syndrome Action Potentials Models Biological QT interval Internal medicine Ca2+/calmodulin-dependent protein kinase Internal Medicine medicine Homeostasis Humans Proarrhythmia Voltage-dependent calcium channel business.industry Myocardium Prolongation Arrhythmias Cardiac Heart medicine.disease Cyclic AMP-Dependent Protein Kinases Long QT Syndrome Endocrinology Calcium-Calmodulin-Dependent Protein Kinases cardiovascular system Cardiology Calcium Calcium Channels Calcium-Calmodulin-Dependent Protein Kinase Type 2 business |
| Zdroj: | Journal of Internal Medicine. 259:81-90 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | QT interval prolongation is incontrovertibly linked to increased risk of arrhythmias but, paradoxically, QT interval prolongation can also be an effective antiarrhythmic strategy and is in fact the goal of class III antiarrhythmic drugs. This discussion examines the cellular effects of QT interval prolongation and proposes that calmodulin kinase II (CaMKII) is a specific cellular proarrhythmic signal that is activated downstream to QT interval prolongation. Inhibition of CaMKII can prevent cellular arrhythmia surrogates and in vivo arrhythmias linked to excessive action potential prolongation, suggesting that QT interval prolongation alone does not fully account for proarrhythmia. This reasoning points to the conclusion that QT interval modulation and prolongation not only grades cellular Ca2+ entry for cardiac contraction but also has the potential to recruit Ca2+-activated signalling molecules. CaMKII is one of these molecules and CaMKII activity is at least partially responsible for the proarrhythmic consequences of excessive QT interval prolongation. |
| Databáze: | OpenAIRE |
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