BK Virus Infection and Its Effect on Renal Function in Pediatric Liver-Transplant Recipients: A Cross-Sectional, Longitudinal, Prospective Study
| Autor: | Achiya Z. Amir, Lester M. Shulman, Ran Steinberg, Hava Fleishhacker, Rivka Shapiro, Eytan Mor, Rachel Bergerin, Yaron Avitzur |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent viruses medicine.medical_treatment Renal function Viremia Liver transplantation medicine.disease_cause Internal medicine Prevalence medicine BK Virus Infection Humans Longitudinal Studies Prospective Studies Child Prospective cohort study Polyomavirus Infections Transplantation business.industry Infant virus diseases medicine.disease Liver Transplantation BK virus Tumor Virus Infections Cross-Sectional Studies BK Virus Child Preschool Female business Viral load |
| Zdroj: | Transplantation. 92:943-946 |
| ISSN: | 0041-1337 |
| Popis: | Background Chronic renal failure (CRF) is a well-documented complication of liver transplantation. BK virus (BKV) is a common cause of CRF in renal-transplant recipients and has been sporadically associated with renal failure after nonrenal solid-organ transplantation. The aims of the study were to determine the prevalence of BK viruria and viremia in pediatric liver-transplant recipients, assess the natural course of BKV infection over time, and examine the association between BKV positivity and renal function. Methods A prospective, cross-sectional study of 59 pediatric liver-transplant recipients. Blood and urine samples were collected at enrollment for creatinine level and BKV polymerase chain reaction test. BKV-positive patients underwent repeated testing and follow-up. The medical files were reviewed for clinical data. Results Median age at enrollment was 11.5 years, and median time from transplantation was 61 months. One child (1.7%) had viremia, and nine children (15.3%) had viruria (median: 610 copies/mL). All cases of viruria/viremia resolved spontaneously, nine of them within 10 months. There were no significant differences in demographic or clinical variables between the BKV-positive and BKV-negative children. None of the BKV-positive patients had evidence of renal dysfunction. Conclusions Pediatric liver-transplant recipients have a low prevalence of BK viruria/viremia. BKV infection is associated with low viral loads and resolves spontaneously within a relatively short period, without residua. BKV is not associated with CRF postliver transplantation. BKV testing should not be part of the routine follow-up of children after liver transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|