The Mastomys natalensis Papillomavirus: Nucleotide Sequence, Genome Organization, and Phylogenetic Relationship of a Rodent Papillomavirus Involved in Tumorigenesis of Cutaneous Epithelia
| Autor: | Ruth Tachezy, Hans-Ulrich Bernard, Shih Yen Chan, Robert D. Burk, Marc Van Ranst, Chiew Hoon Tan |
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| Rok vydání: | 1994 |
| Předmět: |
Skin Neoplasms
Genes Viral Molecular Sequence Data Genome Viral Regulatory Sequences Nucleic Acid Biology Open Reading Frames Viral Proteins Sequence Homology Nucleic Acid Virology medicine Animals Amino Acid Sequence Cloning Molecular Papillomaviridae Gene Peptide sequence Genomic organization Genetics Base Sequence Nucleic acid sequence Cottontail rabbit papillomavirus virus diseases Sequence Analysis DNA Epidermodysplasia verruciformis biology.organism_classification medicine.disease Muridae Keratoacanthoma Mastomys Carcinoma Squamous Cell Sequence Alignment |
| Zdroj: | Virology. 198:534-541 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.1994.1064 |
| Popis: | Mastomys natalensis is a rodent of African origin afflicted with a very high incidence of skin tumors (keratoacanthomas and squamous carcinomas), which are associated with a papillomavirus, M. natalensis papillomavirus (MnPV). We have determined the genomic sequence of MnPV, which has a size of 7687 bp. The genomic organization is similar to that of other papillomaviruses, with open reading frames E6, E7, E1, E2, and E4 in the early and L2 and L1 in the late region. Due to an unusually large hinge region, the transcriptional activator E2 has a size of 542 amino acids rather than 400 to 460 amino acids, as in other papillomaviruses. An open reading frame E5 coding for a small hydrophobic membrane protein is missing, as is the case for some cutaneous human papillomaviruses (HPV). This fact, together with the composition of cis-responsive elements in its long control region and phylogenetic evaluation of segments of its E6, E1, and L1 genes, indicates a relationship of MnPV to the cottontail rabbit papillomavirus and several HPV types found in lesions of cutaneous epithelia, in particular to those that are associated with epidermodysplasia verruciformis. MnPV may be a useful model system for tumorigenesis of cutaneous epithelia in humans. |
| Databáze: | OpenAIRE |
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