Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons
| Autor: | Arturo Alvarez-Buylla, Arnold R. Kriegstein, Miguel Turrero García, Emanuele Mazzola, Philip R.L. Parker, Luis C. Fuentealba, Constance L. Cepko, Corey C. Harwell, Caitlyn C. Gertz, Adrian Gonzalez-Cerrillo |
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| Rok vydání: | 2015 |
| Předmět: |
Telencephalon
Nerve net Mice Neural Stem Cells Cell Movement Transduction Genetic Psychology Cells Cultured Cerebral Cortex Cultured Neocortex Cerebrum General Neuroscience musculoskeletal neural and ocular physiology Neural stem cell medicine.anatomical_structure Embryo Neurological Stem Cell Research - Nonembryonic - Non-Human Cognitive Sciences Cell type Cells 1.1 Normal biological development and functioning Neuroscience(all) Green Fluorescent Proteins Nerve Tissue Proteins Laser Capture Microdissection Biology In Vitro Techniques Inhibitory postsynaptic potential Article Transduction Organ Culture Techniques Genetic Underpinning research Fate mapping Interneurons medicine Animals Cell Lineage Neurology & Neurosurgery Mammalian fungi Neurosciences Neural Inhibition Stem Cell Research Embryo Mammalian nervous system Forebrain Nerve Net Neuroscience |
| Zdroj: | Neuron, vol 87, iss 5 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2015.07.030 |
| Popis: | SummaryThe mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin. |
| Databáze: | OpenAIRE |
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