Dissolution and physicochemical stability enhancement of artemisinin and mefloquine co-formulation via nano-confinement with mesoporous SBA-15
| Autor: | Reginald B. H. Tan, Wai Kiong Ng, Kumaran Letchmanan, Shoucang Shen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Scanning electron microscope Chemistry Pharmaceutical Excipient 02 engineering and technology 010402 general chemistry 01 natural sciences Dosage form Antimalarials Colloid and Surface Chemistry Drug Stability Microscopy Electron Transmission X-Ray Diffraction medicine Physical and Theoretical Chemistry Solubility Particle Size Dissolution Supersaturation Surfaces and Interfaces General Medicine Mesoporous silica 021001 nanoscience & nanotechnology Silicon Dioxide Artemisinins 0104 chemical sciences Nanostructures Mefloquine Crystallography Drug Liberation Chemical engineering Microscopy Electron Scanning 0210 nano-technology Mesoporous material Porosity Biotechnology medicine.drug |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 155 |
| ISSN: | 1873-4367 |
| Popis: | The objective of this study is to enhance the dissolution rate, supersaturation and physicochemical stability of combination of two poorly water-soluble anti-malarial drugs, artemisinin (ART) and mefloquine (MFQ), by encapsulating them inside mesoporous silica (SBA-15) via co-spray drying. Characteristic studies such as powder X-ray diffraction (PXRD), transmission electron microscopy (TEM) and scanning electron microscope (SEM) clearly indicate the amorphization of the crystalline drugs. ART/MQF/SBA-15 formulations show a superior dissolution enhancement with a burst release of more than 95% of drugs within 30min. In addition, the combination formulation exhibits a stable supersaturation enhancement by 2-fold higher than that of the untreated crystalline counterparts. ART/MQF/SBA-15 samples possess excellent physicochemical stability under 2 different moderate storage conditions for 6 months. The amorphization of ART and MFQ via nano-confinement using mesoporous SBA-15 is a potentially promising approach to enhance the solubility of poorly water-soluble anti-malarial drugs that co-formulated into a single dosage form. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect