Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 m-RNA expression in oral cancer
| Autor: | Kinjal D. Patel, Jayendra B. Patel, Prabhudas S. Patel, Yesha V. Barasiya |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Perineural invasion Malignant transformation 03 medical and health sciences 0302 clinical medicine Tongue Humans Medicine Clinical significance RNA Messenger Stage (cooking) General Dentistry Adaptor Proteins Signal Transducing business.industry Cancer 030206 dentistry Cell Biology General Medicine medicine.disease 030104 developmental biology medicine.anatomical_structure Rna expression Otorhinolaryngology Apoptosis Cancer research Mouth Neoplasms Apoptosis Regulatory Proteins business |
| Zdroj: | Archives of Oral Biology. 119:104920 |
| ISSN: | 0003-9969 |
| Popis: | Objective The present study was carried out to unfold the clinical significance of apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 expression in oral cancer (OC). Methods Tissue specimens (malignant and their corresponding adjacent normal) from 40 pathologically confirmed OC patients treated at the Institute were included in the study. ASPP1 and ASPP2 expression were examined using semi-quantitative RT-PCR. Results The results indicated lower ASPP1 expression in OC tissues as compared to adjacent normal tissues (p = 0.085). Stratified analysis as per tumor site revealed significant down-regulation of ASPP1 in tongue cancer tissues (p = 0.005). Receiver operating characteristic curve depicted significant discriminatory efficacy in distinguishing tongue cancer tissues and adjacent normal tissues (p = 0.019). Moreover, ASPP1 expression was remarkably declined in stage II, III and IV OC tumors than stage I OC tumors (p = 0.007, 0.092 and 0.013, respectively). A similar trend was observed in buccal mucosa tumors on further analysis. ASPP2 expression was lower in moderately differentiated OC tumors as compared to well differentiated OC tumors (p = 0.061). Significantly reduced ASPP2 expression was observed in tongue cancer tumors without invasion in contrast to tumors with perineural invasion (p = 0.007). Besides, ASPP1 and ASPP2 expression was positively inter-correlated in tongue tissues (r = 0.325, p = 0.091). Conclusions Lower ASPP1 expression in tongue cancer during malignant transformation has significance in cancer initiation. Association of reduced ASPP1 and ASPP2 expression with advanced disease stage and moderate differentiation suggests their role in OC progression. Thus, down-regulation of ASPP1 and ASPP2 may serve as potential diagnostic and prognostic indicators in OC. |
| Databáze: | OpenAIRE |
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