Use of various models forin vitropercutaneous absorption studies of ultraviolet filters
| Autor: | Véronique Andrieu, Srei Pisei Huong, Jean-Dominique Fourneron, Jean-Pierre Reynier, Hot Bun |
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| Rok vydání: | 2009 |
| Předmět: |
integumentary system
Ultraviolet Rays Chemistry Administration Topical Skin Absorption Drug Evaluation Preclinical Synthetic membrane Human skin Dermatology Penetration (firestop) Anatomy Permeation In vitro Artificial skin Membrane Species Specificity In vivo Models Animal Animals Humans Sunscreening Agents Skin Tests Biomedical engineering |
| Zdroj: | Skin Research and Technology. 15:253-261 |
| ISSN: | 1600-0846 0909-752X |
| DOI: | 10.1111/j.1600-0846.2009.00368.x |
| Popis: | Background: The percutaneous absorption test aims to estimate the passage of a substance across the skin. The absorption process can be described in three steps: (a) penetration of a substance into the skin layer, followed by (b) penetration from one layer into another (permeation) and finally (c) resorption into the vascular system. In vivo and in vitro models are available but owing to ethical reasons as well as the latter providing greater feasibility, in vitro models are preferred. Aims: This present study reviews the natural membranes (human skin and animal models: pig, rabbit, rat, hairless mouse, guinea-pig and mouse), artificial skin equivalents and synthetic membranes that are currently being used for in vitro percutaneous absorption studies of UV filters, in order to provide the researcher with a greater insight when selecting membrane models for given experimental conditions. |
| Databáze: | OpenAIRE |
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