Genetic polymorphism and clinical outcome: identification of individuals at risk of a poor clinical outcome
| Autor: | R C, Strange, J, Alldersea, P R, Hoban, A A, Fryer, C, Matthias, V, Jahnke, P W, Jones |
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| Rok vydání: | 2000 |
| Předmět: |
Molecular Epidemiology
Multifactorial Inheritance Candidate gene Polymorphism Genetic business.industry medicine.medical_treatment Immunology Cancer Immunotherapy medicine.disease Phenotype Gene interaction Head and Neck Neoplasms Risk Factors medicine Humans Immunology and Allergy Epistasis Genetic Predisposition to Disease Allele business Gene |
| Zdroj: | Allergy. 55:10-14 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | Susceptibility and outcome in complex disorders such as asthma and cancer appear to be determined, at least in part, by genetic polymorphism. However, while our ability to identify new allelic variants and study them in case and control populations has greatly improved, considerable difficulties remain in elucidating how many genes determine particular clinical phenotypes. This is because most studies have concentrated on study of single genes in relatively small study groups. The important issues of gene-gene interactions (epistasis) and high-risk subgroups have not yet been adequately addressed. We now describe a general approach, using patients with head and neck cancers as an example. Our purpose is to demonstrate candidate gene selection, statistical approaches, and identification of patient subgroups. |
| Databáze: | OpenAIRE |
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