Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes
| Autor: | Johan Wouter Jukema, Lisanne L. Blauw, Stella Trompet, Sander Kooijman, Jimmy F.P. Berbée, Anne Tybjærg-Hansen, Raymond Noordam, Gerard Pasterkamp, Gert J. de Borst, Diana van Heemst, Sander W. van der Laan, Patrick C.N. Rensen, Jessica van Setten |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Population lcsh:Medicine 030204 cardiovascular system & hematology MC4R Article Coronary artery disease 03 medical and health sciences BMI 0302 clinical medicine cardiovascular disease Internal medicine medicine Genetics genetics Myocardial infarction Allele education 030304 developmental biology 0303 health sciences education.field_of_study business.industry Vascular disease lcsh:R General Medicine medicine.disease Atherosclerosis Cardiovascular disease Minor allele frequency Population study atherosclerosis business Body mass index |
| Zdroj: | Blauw, L L, Noordam, R, van der Laan, S W, Trompet, S, Kooijman, S, van Heemst, D, Jukema, J W, van Setten, J, de Borst, G J, Tybjærg-Hansen, A, Pasterkamp, G, Berbée, J F P & Rensen, P C N 2021, ' Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes ', Journal of Clinical Medicine, vol. 10, no. 5, 932 . https://doi.org/10.3390/jcm10050932 Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 932, p 932 (2021) Volume 10 Issue 5 Journal of Clinical Medicine, 10(5). MDPI |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10050932 |
| Popis: | We analyzed the effects of the common BMI-increasing melanocortin 4 receptor (MC4R) rs17782313-C allele with a minor allele frequency of 0.22–0.25 on (1) cardiovascular disease outcomes in two large population-based cohorts (Copenhagen City Heart Study and Copenhagen General Population Study, n = 106,018 and UK Biobank, n = 357,426) and additionally in an elderly population at risk for cardiovascular disease (n = 5241), and on (2) atherosclerotic plaque phenotypes in samples of patients who underwent endarterectomy (n = 1439). Using regression models, we additionally analyzed whether potential associations were modified by sex or explained by changes in body mass index. We confirmed the BMI-increasing effects of +0.22 kg/m2 per additional copy of the C allele (p < 0.001). However, we found no evidence for an association of common MC4R genetic variation with coronary artery disease (HR 1.03 95% CI 0.99, 1.07), ischemic vascular disease (HR 1.00 95% CI 0.98, 1.03), myocardial infarction (HR 1.01 95% CI 0.94, 1.08 and 1.02 0.98, 1.07) or stroke (HR 0.93 95% CI 0.85, 1.01), nor with any atherosclerotic plaque phenotype. Thus, common MC4R genetic variation, despite increasing BMI, does not affect cardiovascular disease risk in the general population or in populations at risk for cardiovascular disease. |
| Databáze: | OpenAIRE |
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