Differences in Clinical Characteristics and Therapy of Neonatal Acute Respiratory Distress Syndrome (ARDS) and Respiratory Distress Syndrome (RDS): A Retrospective Analysis of 925 Cases
| Autor: | Zhichun Feng, Jia Chen, Qiu-ping Li, Jinghua Luo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty ARDS Therapeutics Acute respiratory distress 030204 cardiovascular system & hematology Group A Group B 03 medical and health sciences 0302 clinical medicine Clinical Research Internal medicine medicine Humans Retrospective Studies Respiratory Distress Syndrome Newborn Respiratory Distress Syndrome Respiratory distress business.industry Incidence (epidemiology) Respiratory Distress Syndrome Adult Infant Newborn Gestational age Retrospective cohort study General Medicine medicine.disease Systemic Inflammatory Response Syndrome 030220 oncology & carcinogenesis Female business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.915213 |
| Popis: | BACKGROUND This study assessed the clinical characteristics of neonatal acute respiratory distress syndrome (ARDS) and differences in therapy in comparison to RDS. MATERIAL AND METHODS The clinical data of 925 preterm infants with respiratory distress were collected and divided into 4 groups. Group A and B both met the diagnosis of neonatal RDS, whereas infants in group B also showed inflammatory response. Group C met the Montreux definition of neonatal ARDS and group D was the control. RESULTS We found that 73.50% of the 925 preterm infants were diagnosed with RDS, of which RDS with inflammatory response accounted for 42.05%. ARDS accounted for 5.29% and control group accounted for 21.19%. Group C infants were the heaviest (2168.16±654.43 g) and had the oldest gestational age. The pregnancy-induced hypertension was highest (30.07%) in group B and lowest in group D (13.26%). Group C had higher iNO and longer invasive ventilator times, but had less frequent surfactant treatment, as well as shorter oxygen time and hospital stay. Group B had significantly longer invasive ventilator use than in Group A. In group A, PDA, ROP, and PPHN were the most common complications, with morbidity rates at 78.35%, 8.4%, and 25.77%, respectively, while group C had higher incidence of PDA (71.42%) and coagulation disorders (38.77%). CONCLUSIONS ARDS mainly occurs in late preterm infants. Its treatment is dependent on iNO and invasive ventilator-assisted therapy, and the surfactant treatment rate was relatively lower in comparison to RDS. RDS accompanied with inflammatory response is also dependent on prolonged use of an invasive ventilator. |
| Databáze: | OpenAIRE |
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