Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
| Autor: | Im Chun Young, Ji Hoon Yu, Sang-Hyun Min |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
prolyl isomerase Review medicine.disease_cause Serine Cell and Developmental Biology 03 medical and health sciences cancer therapeutics 0302 clinical medicine Protein structure PIN1 Cancer stem cell proline-directed phosphorylation medicine Prolyl isomerase Threonine lcsh:QH301-705.5 Chemistry Cell Biology tumorigenesis 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Cancer research Phosphorylation Carcinogenesis Developmental Biology PIN1 inhibitor |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 8 (2020) Frontiers in Cell and Developmental Biology |
| DOI: | 10.3389/fcell.2020.00120/full |
| Popis: | Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds. |
| Databáze: | OpenAIRE |
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