Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells
| Autor: | K. Nakayama, Jwo-Farn Chiou, Ginger E. Dutschman, Susan P. Grill, Kenneth F. Bastow, K B Frank, Yung-Chi Cheng |
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| Rok vydání: | 1984 |
| Předmět: |
DNA polymerase
Guanine viruses Deoxyribonucleotides Acyclovir medicine.disease_cause Antiviral Agents Herpesviridae Virus chemistry.chemical_compound Viral Proteins medicine Humans Simplexvirus Pharmacology (medical) Ganciclovir Pharmacology biology DNA synthesis RNA Virology Molecular biology Infectious Diseases Herpes simplex virus chemistry Thymidine kinase Enzyme Induction DNA Viral biology.protein RNA Viral Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 26(3) |
| ISSN: | 0066-4804 |
| Popis: | We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fashion. This inhibition was not due to the lack of deoxynucleoside triphosphates which are required for DNA synthesis. This compound has no apparent effect on early and late viral RNA synthesis, viral protein synthesis, or viral thymidine kinase, DNA polymerase, and DNase induction in virus-infected cells. |
| Databáze: | OpenAIRE |
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