Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica
| Autor: | Won-Hee Choi, Yeonmi Lee, Youn Ock Jo, Tae-Youl Ha, Sanghyun Lee, Sang Yoon Choi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.drug_class
Ulmus Anti-Inflammatory Agents Medicine (miscellaneous) Nitric Oxide complex mixtures Plant Roots Japonica Anti-inflammatory Dinoprostone chemistry.chemical_compound Mice Ulmus davidiana Phenols Cell Line Tumor Botany Ulmus davidiana var. japonica medicine Animals Medicinal plants Bakuchiol Inflammation Nutrition and Dietetics biology Traditional medicine Plant Stems Chemistry Plant Extracts fungi Traditional Korean medicine food and beverages biology.organism_classification visual_art visual_art.visual_art_medium Plant Bark Bark |
| Zdroj: | Journal of medicinal food. 13(4) |
| ISSN: | 1557-7600 |
| Popis: | The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol (50 microM) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica. |
| Databáze: | OpenAIRE |
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