A New Hope in Spinal Degenerative Diseases: Piezo1
| Autor: | Yidian Wang, Daxue Zhu, Ming-Qiang Liu, Xuewen Kang, Xudong Guo, Guangzhi Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nucleus Pulposus
Stimulation Review Article Ion Channels General Biochemistry Genetics and Molecular Biology Cell membrane Mice Chondrocytes Mechanosensitive ion channel Degenerative disease medicine Animals Humans Osteoblasts General Immunology and Microbiology Cell growth business.industry Mesenchymal stem cell PIEZO1 General Medicine medicine.disease medicine.anatomical_structure Apoptosis Medicine Spinal Diseases Stress Mechanical business Neuroscience |
| Zdroj: | BioMed Research International, Vol 2021 (2021) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | As a newly discovered mechanosensitive ion channel protein, the piezo1 protein participates in the transmission of mechanical signals on the cell membrane and plays a vital role in mammalian biomechanics. Piezo1 has attracted widespread attention since it was discovered in 2010. In recent years, studies on piezo1 have gradually increased and deepened. In addition to the discovery that piezo1 is expressed in the respiratory, cardiovascular, gastrointestinal, and urinary systems, it is also stably expressed in cells such as mesenchymal stem cells (MSCs), osteoblasts, osteoclasts, chondrocytes, and nucleus pulposus cells that constitute vertebral bodies and intervertebral discs. They can all receive external mechanical stimulation through the piezo1 protein channel to affect cell proliferation, differentiation, migration, and apoptosis to promote the occurrence and development of lumbar degenerative diseases. Through reviewing the relevant literature of piezo1 in the abovementioned cells, this paper discusses the effect of piezo1 protein expression under mechanical stress stimuli on spinal degenerative disease, providing the molecular basis for the pathological mechanism of spinal degenerative disease and also a new basis, ideas, and methods for the prevention and treatment of this degenerative disease. |
| Databáze: | OpenAIRE |
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