Improving the diagnosis of high grade and stage bladder cancer by detecting increased urinary calprotectin expression in tumor tissue and tumor-associated inflammatory response
Autor: | Yusuf Sahin, Mustafa Kadihasanoglu, Mahmut Gokhan Toktas, Esma Yucetas, Mustafa Zafer Temiz, Huseyin Aytac Ates, Ugur Yucetas, Birsen Cigdem Topkaya, Erkan Erkan |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Urological Oncology Urology Urinary system Urinary bladder neoplasms 030232 urology & nephrology Urine lcsh:RC870-923 Gastroenterology 03 medical and health sciences 0302 clinical medicine fluids and secretions Internal medicine Medicine Trigone of urinary bladder Humans Stage (cooking) Aged Neoplasm Staging Retrospective Studies Aged 80 and over Inflammation Calprotectin Bladder cancer Receiver operating characteristic business.industry Middle Aged lcsh:Diseases of the genitourinary system. Urology medicine.disease 030220 oncology & carcinogenesis Biomarker (medicine) Female Original Article Neoplasm Grading business Leukocyte L1 Antigen Complex Biomarkers |
Zdroj: | Investigative and Clinical Urology Investigative and Clinical Urology, Vol 60, Iss 5, Pp 343-350 (2019) |
ISSN: | 2466-054X |
Popis: | Purpose To investigate whether measurement of urinary calprotectin can serve as a biomarker in the diagnosis of primary bladder cancer and to confirm its diagnostic role in determining high grade and stage disease. Materials and methods Urinary calprotectin was measured in spot urine samples from patients with primary bladder cancer and control subjects. To confirm levels in urine, tissue samples were also obtained from bladder tumor and healthy trigone of bladder by transurethral resection in both groups. Finally, calprotectin levels in tissue and urine of the patients and control subjects were compared and their diagnostic potential was investigated in high grade and stage bladder cancers. Results Of 82 participants, 52 were patients with bladder cancer and 30 were control subjects. The two groups were comparable in terms of age, smoking status, and comorbidities. Tissue and urinary calprotectin levels were significantly higher in the bladder cancer group. In subgroup analyses, urinary calprotectin levels were significantly higher in patients with high-grade, muscle-invasive tumors. After receiver operating characteristic analyses, the sensitivity and specificity of urinary calprotectin was 100% and 96.7%, respectively, in the diagnosis of primary bladder cancer. High grade and stage bladder cancers were detected with sensitivity and specificity of 70% and 74.2%, and 80% and 84.8%, respectively. Conclusions Urinary calprotectin may be a valuable parameter in the diagnosis of primary bladder cancer with high sensitivity and specificity. Furthermore, it may be useful in the prediction of high grade and stage disease. However, more investigations are needed. |
Databáze: | OpenAIRE |
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