| Autor: |
Pinckney, Lauren, Collins, Justin, Schammel, Christine, Gevaert, Matt, Schammel, David, W. Edenfield, Jeffrey Elder, Puls, Larry |
| Rok vydání: |
2018 |
| DOI: |
10.6084/m9.figshare.7040849 |
| Popis: |
Figure S1. ALK and KMT2D (MLL2) converge on CTNNB1. An evaluation of the potential role of the gene products from mutated genes in our cohort that are associated with negative outcomes was completed to potentially identify pathways that could be targeted for novel therapy in this young group. StringÂŽ, a protein-protein network modeling website sponsored by the String Consortium and the Swiss Institute of Bioinformatics (SIB) [ http://string-db.org ], was used to postulate how the gene mutations were connected in biochemical pathways that could potentially create the carcinogenic phenotype. In our cohort, ALK and KMT2D (MLL2) gene mutations were found to be associated with both ovarian and endometrial negative outcomes in patients with neuroendocrine histology. In the String program, the ALK and KMT2D proteins, while being involved in multiple pathways, appear to converge on CTNNB1, a key member of the Wnt pathway. The Wnt pathway is important in cell adhesion and maintenance of an appropriate cell cycle and has been found to be compromised in a variety of cancers. Additionally, dysregulation of the Wnt pathway has recently been implicated in maintenance of cancer stem cells, metastasis and immune control (Zhan T et al., Oncogene 2017; 36:1461â 1473). The String algorithm also revealed that HSP90AA1 is also involved in this complex pathway. HSP90AA1 has been shown to be a prognostic indicator of both liver and breast cancers. ( https://www.proteinatlas.org/ENSG00000080824-HSP90AA1/pathology ) (DOCX 687 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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