Reduced glandular kallikrein-like activity in the anterior pituitary of the new zealand genetically hypertensive rat
| Autor: | Philip G. Baer, C. Andrew Powers, Alberto Nasjletti |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Genetically hypertensive rat Biophysics Cell Biology Biology Biochemistry Rats Mutant Strains Rats Peptide substrate Sex Factors medicine.anatomical_structure Endocrinology Anterior pituitary Pituitary Gland Anterior Reference Values Internal medicine Hypertension medicine Animals Female Kallikreins Molecular Biology Glandular Kallikrein |
| Zdroj: | Biochemical and Biophysical Research Communications. 119:689-693 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(84)80305-8 |
| Popis: | Summary Anterior pituitaries of New Zealand genetically hypertensive and normotensive rats were compared for their content of glandular kallikrein-like activity. Anterior pituitary homogenates were assayed for their ability to cleave a chromogenic peptide substrate for glandular kallikrein (H-D-val-leu-arg-p-nitroanilide) at pH 8.0. Anterior pituitaries of both male and female New Zealand genetically hypertensive rats contained significantly less glandular kallikrein-like activity than their normotensive counterparts (-55% for females and -31% for males). |
| Databáze: | OpenAIRE |
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