The effect of α-naphthylisothiocyanate on bile secretion prior to and during the onset of cholestasis in the rat
| Autor: | Jocelyn Lavigne, Gabriel L. Plaa, Simon Lock |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Bilirubin α naphthylisothiocyanate Erythritol Toxicology digestive system Gastroenterology Bile Acids and Salts Excretion chemistry.chemical_compound Cholestasis 1-Naphthylisothiocyanate Internal medicine medicine Animals Bile Bile secretion Rats Inbred Strains General Medicine medicine.disease Rats Bile acid excretion Endocrinology chemistry Thiocyanates |
| Zdroj: | Toxicology Letters. 10:427-435 |
| ISSN: | 0378-4274 |
| Popis: | The effect of alpha-naphthylisothiocyanate (ANIT) on bile flow, erythritol clearance, bile acid excretion and bilirubin excretion was studied in rats. The median time-to-effect (Et50) for the appearance of cholestasis was about 15 h. ANIT failed to exert a gradual effect on bile flow or erythritol clearance before the onset of cholestasis. However, 3 h before complete cessation of bile flow, a rapid decline in bile flow and bile acid excretion was observed. Bile acid-independent flow was markedly reduced. However, the bile acid-dependent component was also affected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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