Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
| Autor: | Lucija Tudor, Jasna Bingulac-Popović, Marina Lampalo, Nela Pivac, Marcela Konjevod, Sanja Popović-Grle, Jasenka Markeljević, Katherina Bernadette Sreter, Irena Jukić, Hana Safic Stanic, Matea Nikolac Perkovic, Dubravka Švob Štrac |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
aspirin lcsh:Medicine Medicine (miscellaneous) severity Tropomyosin receptor kinase B macromolecular substances BDNF and NTRK2 (TrkB gene) polymorphisms Article 03 medical and health sciences 0302 clinical medicine Neurotrophic factors immune system diseases Genotype medicine Allele Allele frequency Asthma Brain-derived neurotrophic factor Biotechnology in Biomedicine (natural science biomedicine and healthcare bioethics area business.industry musculoskeletal neural and ocular physiology lcsh:R phenotypes asthma plasma BDNF concentration medicine.disease respiratory tract diseases 030104 developmental biology 030228 respiratory system nervous system Immunology business rs6265 |
| Zdroj: | Journal of Personalized Medicine Volume 10 Issue 4 Journal of Personalized Medicine, Vol 10, Iss 189, p 189 (2020) |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm10040189 |
| Popis: | Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses however, their role in asthma remains unclear. Plasma BDNF concentration, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity. |
| Databáze: | OpenAIRE |
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