Recurrence and progression in nonmuscle invasive transitional cell carcinoma of urinary bladder treated with intravesical Bacillus Calmette–Guerin: A single center experience and analysis of prognostic factors
| Autor: | Haya Azouz, Shouki Bazarbashi, Amal H Abu Sabaa, Mohammed F Alotaibi, Ahmad Alzahrani, Ali Aljubran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Urology Bacillus Calmette–Guerin Single Center lcsh:RC870-923 03 medical and health sciences 0302 clinical medicine medicine Univariate analysis Bladder cancer Urinary bladder business.industry Carcinoma in situ Medical record nonmuscle invasive bladder cancer prognostic factors interferon medicine.disease lcsh:Diseases of the genitourinary system. Urology Confidence interval Surgery Transitional cell carcinoma medicine.anatomical_structure 030220 oncology & carcinogenesis Original Article business |
| Zdroj: | Urology Annals, Vol 8, Iss 3, Pp 333-337 (2016) Urology Annals |
| ISSN: | 0974-7834 0974-7796 |
| Popis: | Background: Intravesical Bacillus Calmette–Guerin (BCG) has been the standard of care for the prevention of nonmuscle invasive bladder cancer (NMIBC) recurrence following resection. Attempts to improve on the result by combining it with other agents have largely failed. This study addresses the result of BCG therapy in our patient population and compares the result with our combination BCG and interferon therapy published earlier. Materials and Methods: The medical records of patients diagnosed with NMIBC and treated with transurethral resection and intravesical BCG were reviewed. Univariate analysis was performed on most known prognostic factors. Results were compared to published data on the use of BCG and interferon from the same institution. Results: Thirty-one patients were identified. Median age was 66 (range 33–109), 80.6% were males. Fourteen patients (45%) had ≤ 3 tumors and 18 (58.1%) had T1 lesions. Four patients (12.9%) had Grade 3 tumors and 25 (80.6%) had Grade 2 tumors. One patient (3.2) had concurrent carcinoma in situ and 11 (35.5%) were treated upon initial diagnosis. At 5 years, the relapse-free survival was 61.3% (95% confidence interval (CI) 44.2–78.4%), progression-free survival was 85.6% (95% CI 73.3–97.9%), and overall survival was 93% (95% CI 84.1–100%). Comparison with the BCG and interferon data showed no significant difference. Conclusion: The result of BCG therapy in our patient population is similar to western reported data. Efficacy of BCG alone is equal to BCG and interferon within our institution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|