The curative effect of androgen deprivation therapy alone is insufficient in high-risk prostate cancer
| Autor: | Dalsan You, Jung Hoon Kim, Wonchul Lee, Yoon Soo Kyung, Se Young Choi, Byung Hoon Chi, Choung-Soo Kim, Bumjin Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biochemical recurrence
Male medicine.medical_specialty Multivariate analysis medicine.medical_treatment Urology Observational Study Kaplan-Meier Estimate androgen deprivation therapy Risk Assessment Androgen deprivation therapy Prostate cancer high-risk Republic of Korea Biomarkers Tumor Medicine Humans Aged Neoplasm Staging Proportional Hazards Models Radiotherapy prostatectomy business.industry Prostatectomy Proportional hazards model Patient Selection Hazard ratio Prostatic Neoplasms Androgen Antagonists General Medicine Prostate-Specific Antigen medicine.disease prostate cancer Combined Modality Therapy Prostatic Neoplasms Castration-Resistant Outcome and Process Assessment Health Care localized Cohort business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | To compare the outcomes of patients with high-risk prostate cancer treated by primary radical prostatectomy (RP) and primary androgen deprivation therapy (ADT). The study included patients with high-risk or very high-risk prostate cancer. Patients treated with definitive radiation therapy and those with clinical N1 and M1 disease were excluded. The RP group was divided into sub-cohorts of patients treated with ADT and those who received ADT after biochemical recurrence post-RP. Cancer-specific survival (CSS) and overall survival (OS) were analyzed using the Kaplan–Meier method and the Cox proportional hazards model. The study analyzed 859 patients divided into the RP group (n = 654) and ADT group (n = 205). Castration-resistant prostate cancer was detected in 23 (3.5%) patients in the RP group and 43 (21.0%) patients in the ADT group. Mortality cases included 63 (9.6%) patients in the RP group and 91 (44.4%) patients in the ADT group. CSS (P = .0002) and OS (P |
| Databáze: | OpenAIRE |
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