Secretion pathway of liver IGF-1 via JAK2/STAT3 in chick embryo under the monochromatic light
| Autor: | Jing Cao, Zixu Wang, Yulan Dong, Tuanjie Wang, Yaoxing Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
STAT3 Transcription Factor
0301 basic medicine medicine.medical_specialty Light Clinical Biochemistry Receptors Melatonin Chick Embryo Biology Melatonin 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Animals Secretion Insulin-Like Growth Factor I STAT3 Receptor Cells Cultured chemistry.chemical_classification Reactive oxygen species Embryo Cell Biology Janus Kinase 2 In vitro 030104 developmental biology medicine.anatomical_structure Liver chemistry Hepatocyte Hepatocytes biology.protein Reactive Oxygen Species hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Growth Factors. 34:51-63 |
| ISSN: | 1029-2292 0897-7194 |
| Popis: | This study reveals mechanism of monochromatic light on the IGF-1 secretion of chick embryo liver. The chick embryos were incubated and exposed to continuous red, green, blue light or a dark environment. Compared to other light-treated groups, green light increased IGF-1 and melatonin concentrations both in plasma and liver, and Mel1a, Mel1b and Mel1c receptors expressions in liver but decreased p-JAK2, p-STAT3 and ROS in liver. IGF-1 had a positive correlation with melatonin, but a negative relevance with p-JAK2 and p-STAT3. In vitro, the IGF-1 level in the hepatocyte supernatant was enhanced by melatonin with lower p-JAK2/p-STAT3 and ROS levels, which was suppressed by Mel1c antagonist but not Mel1a/Mel1b or Mel1b antagonists. AG490 (JAK/STAT inhibitor) promoted role of melatonin-Mel1c modulated IGF-1 secretion. These results suggest the antioxidant effect of melatonin mediated the green light-enhanced IGF-1 secretion of chick embryo liver through Mel1c receptor to inhibit the JAK2/STAT3 pathway. |
| Databáze: | OpenAIRE |
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