PROSPECTS FOR APPLICATION OF BOVINE PERICARDIAL SCAFFOLD FOR CARDIAL SURGERY
Autor: | I. M. Yemets, A. A. Dovghaliuk, D. A. Grekov, N. M. Rudenko, G. I. Yemets, N. V. Shchotkina, A. A. Sokol |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0303 health sciences
Scaffold medicine.medical_specialty Decellularization business.industry tissue engineering lcsh:Biotechnology cardioimplant 02 engineering and technology scaffold 021001 nanoscience & nanotechnology Surgery 03 medical and health sciences medicine.anatomical_structure Tissue engineering lcsh:TP248.13-248.65 medicine cardiovascular system Pericardium decellularization 0210 nano-technology business 030304 developmental biology |
Zdroj: | Biotechnologia Acta, Vol 13, Iss 6, Pp 41-49 (2020) |
ISSN: | 2410-7751 |
Popis: | The aim of the\* study was to estimate the properties of the scaffold obtained by decellularization of bovine pericardium with a 0.1% solution of sodium dodecyl sulfate. The experiment included standard histological, microscopic, molecular genetic, and biomechanical methods. Scaffold was tested in vitro for cytotoxicity and in vivo for biocompatibility. A high degree of removal of cells and their components from bovine pericardium-derived matrix was shown. Biomechanical characteristics of artificial scaffold were the same as those of the native pericardium. With prolonged contact, no cytotoxic effect on human cells was observed. The biointegration of the scaffold in laboratory animals tissues was noted, which confirms the potential possibility of the implant applicationin cardiac surgery. |
Databáze: | OpenAIRE |
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