MR imaging of late radiation therapy- and chemotherapy-induced injury: a pictorial essay
| Autor: | Boris Rychlý, Juraj Šteňo, E. Bolješíková, V. Belan, M. Chorváth, P. Kalina, I. Makaiová, V. Pročka, Ľ. Pružincová, M. Novotný, M. Srbecký |
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| Rok vydání: | 2008 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Adult Diagnostic Imaging Male medicine.medical_specialty Magnetic Resonance Spectroscopy Drug-Related Side Effects and Adverse Reactions medicine.medical_treatment Antineoplastic Agents Necrosis Medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Neuroradiology medicine.diagnostic_test business.industry Brain Neoplasms Brain Interventional radiology General Medicine Middle Aged Magnetic Resonance Imaging Radiation therapy Diffusion Magnetic Resonance Imaging Tumor progression Dynamic contrast-enhanced MRI Female Radiology business Perfusion Diffusion MRI |
| Zdroj: | European radiology. 19(11) |
| ISSN: | 1432-1084 |
| Popis: | Radiation to the brain and adjuvant chemotherapy may produce late delayed changes from several months to years after treatment of intracranial malignancies with a reported prevalence of 5-24%. The pattern of treatment-related injury may vary from diffuse periventricular white matter lesions to focal or multifocal lesions. Differentiation of treatment-related injury from tumor progression/recurrence may be difficult with conventional MR imaging (MRI). With both disease processes, the characteristic but nonspecific imaging features are vasogenic edema, contrast enhancement, and mass effect. This pictorial essay presents MRI spectra of late therapy-induced injuries in the brain with a particular emphasis on radiation necrosis, the most common and severe form. Novel MRI techniques, such as diffusion-weighted imaging (DWI), proton MR spectroscopy (MRS), and perfusion MRI, improve the possibilities of better characterization of treatment-related changes. Advanced MRI techniques allow for the assessment of metabolism and physiology and may increase specificity for therapy-induced changes. |
| Databáze: | OpenAIRE |
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