Allogeneic marrow grafting with partially mismatched, unrelated marrow donors
| Autor: | RD Gingrich, GD Ginder, NE Goeken, CW Howe, BC Wen, DH Hussey, MA Fyfe |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Adolescent Immunology Graft vs Host Disease Pilot Projects Infections Biochemistry Postoperative Complications Preoperative Care Humans Transplantation Homologous Child Bone Marrow Transplantation Leukemia Histocompatibility Testing Graft Survival Anemia Aplastic Cell Biology Hematology Middle Aged Iowa Tissue Donors surgical procedures operative Child Preschool Histocompatibility Female |
| Zdroj: | Blood. 71(5) |
| ISSN: | 0006-4971 |
| Popis: | Forty patients with advanced hematologic malignancies or severe aplastic anemia received marrow grafts from partially mismatched, unrelated marrow donors. All patients were administered conventional prophylaxis for acute graft-v-host disease (GVHD) consisting of methotrexate and low-dose glucocorticoids. All but two patients who survived at least 30 days showed durable engraftment. Six patients survive 17+ to 36+ months following transplantation. Severe acute GVHD was seen in 47% of the patients; however, no direct correlation between GVHD and the degree of mismatching could be determined. Fatal infections were seen in 29 patients, and in the majority the infection occurred after the granulocyte count had risen to greater than 500 cells/microL. We conclude that the problems encountered in this pilot study can potentially be solved, and that further studies with this type of marrow grafting are warranted. |
| Databáze: | OpenAIRE |
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